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Immunomodulation: An immune regulatory mechanism in carcinoma therapeutics

Rana M Alsaffar1, Shafat Ali2, Summya Rashid1

  • 1Department of Pharmacology & Toxicology, College of Pharmacy Girls Section, Prince Sattam Bin Abdulaziz University, P.O. Box-173, Al-Kharj-11942, Saudi Arabia.

International Immunopharmacology
|July 25, 2021
PubMed

Insights

Cancer progression involves disrupted signaling pathways and immune system dysregulation. Targeted therapies and immunotherapy offer promising strategies for cancer treatment by modulating these pathways and harnessing immune responses.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer is characterized by numerous mutations affecting critical signaling pathways.
  • Deregulated immunological signaling is a key factor in cancer development and progression.
  • Signaling pathways function as modular networks with protein interactions regulating cellular processes.

Purpose of the Study:

  • To explore the role of signaling pathways in cancer.
  • To highlight the potential of immunotherapy in cancer treatment.
  • To identify targeted therapies for cancer management.

Main Methods:

  • Review of genetic, epigenetic, and transcriptomic alterations impacting signaling pathways.
  • Analysis of cancer immunotherapy strategies.
  • Investigation of small molecules targeting key signaling pathways.

Main Results:

  • Signaling pathway alterations, driven by genetic and epigenetic changes, contribute to cancer progression.
  • Immunotherapy effectively targets cancer cells by leveraging the immune system.
  • Specific small molecules demonstrate potential in regulating signaling pathways for cancer management.

Conclusions:

  • Targeted therapies and immunotherapy are crucial for effective cancer treatment.
  • Modulating key signaling pathways offers a promising avenue for managing various carcinomas.
  • Understanding signaling pathway dynamics is vital for developing novel cancer therapies.
Keywords:
Astragaloside-IVGalunisertibImmunityImmunomodulationJervineMelatoninTumor

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