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Histological composition behind CT-based thrombus density and perviousness in acute ischemic stroke
Gengfan Ye1, Ruoyao Cao2, Jun Lu3
1Department of Neurosurgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, PR China.
Clinical Neurology and Neurosurgery
|July 25, 2021
Summary
Pre-treatment imaging markers like relative thrombus density correlate with clot composition (erythrocytes). However, hyperdense artery sign and clot perviousness did not significantly impact thrombectomy outcomes.
Area of Science:
- Neuroradiology
- Cerebrovascular Diseases
- Medical Imaging
Background:
- Clot composition influences mechanical thrombectomy outcomes.
- Preoperative imaging may predict histological thrombus components.
Purpose of the Study:
- To investigate the association between preoperative imaging markers and clot composition in patients undergoing thrombectomy.
- To evaluate if imaging markers predict recanalization and clinical outcomes.
Main Methods:
- Retrospective review of thrombectomy patients (June 2017-December 2019).
- Analysis of non-enhanced CT (relative thrombus density) and contrast-enhanced CT (clot perviousness).
- Correlation with histological clot components (Martius Scarlet Blue staining).
Main Results:
- Relative thrombus density positively correlated with erythrocyte fractions (p=0.014).
- Clot perviousness negatively correlated with platelet fractions (p<0.001).
- Hyperdense artery sign and clot perviousness did not significantly associate with recanalization or clinical outcomes (mRS 0-2).
Conclusions:
- Relative thrombus density and clot perviousness are associated with specific clot compositions.
- Imaging markers did not predict thrombectomy success or patient outcomes in this cohort.
- Further research is needed to confirm these findings.
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