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Updated: Oct 26, 2025
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India
Kumar Jeyaprakash1, Thennarasu Shanthini2, Usha Kim3
1Department of Molecular Genetics, Aravind Medical Research Foundation, Madurai; Department of Molecular Biology, Aravind Medical Research Foundation, Affiliated to Alagappa University, Karaikudi, India.
Purpose:
This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.
Methods:
One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.
Results:
Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome.
Conclusion:
Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.
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