Triggered interactions between nanoparticles and lipid membranes: design principles for gel formation or...

Lipid bilayer vesicles offer exciting possibilities for stimulated response, taking advantage of the membrane's flexibility and impermeability. We show how synergistic interactions between vesicles and polymer-based nanoparticles can be triggered at the nanoscale using UV light. This interaction leads either to adhesion and a membrane-based gel, or to nanoscale wrapping of the particles by the membrane and then vesicle destruction. To map the response, we varied the particle-membrane interactions via their surface charge densities. We found a crossover from adhesion to destruction at a well-defined region in parameter space. We modeled these results by accounting for the electrostatic attraction and the energy of membrane bending. We then synthesized amphiphilic polymers containing a UV-responsive nitrobenzyl moiety that switches its charge, and showed how a trigger predictably led to either a vesicle gel or disruption and release. The results pave the way to a new triggering mechanism and new response modes in soft materials.