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Related Experiment Videos

Cefonicid vs. cefoxitin for cesarean section prophylaxis.

R A Hartert1, G Benrubi, R J Thompson

  • 1Department of Obstetrics and Gynecology, University Hospital of Jacksonville, Florida 32209.

The Journal of Reproductive Medicine
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

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Cefonicid and cefoxitin showed similar efficacy for cesarean section prophylaxis, with no significant difference in endometritis or febrile morbidity rates. Cefonicid is a cost-effective alternative for preventing postpartum infections.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Cesarean section prophylaxis is crucial for preventing postpartum infections.
  • Second-generation cephalosporins are commonly used for surgical prophylaxis.
  • Comparing long-acting versus short-acting agents is important for optimizing treatment regimens.

Purpose of the Study:

  • To compare the efficacy and safety of cefonicid (long-acting) versus cefoxitin (short-acting) for cesarean section prophylaxis.
  • To evaluate the incidence of endometritis and febrile morbidity in patients receiving either antibiotic.

Main Methods:

  • A randomized, prospective study involving 139 patients undergoing cesarean section.
  • Group 1 received a single 1-g intravenous dose of cefonicid post-cord clamping.

Related Experiment Videos

  • Group 2 received a 2-g intravenous dose of cefoxitin post-cord clamping and at 6, 12, and 18 hours postpartum.

    • Main Results:

    • Endometritis incidence was 17.3% with cefonicid vs. 12.1% with cefoxitin (P > .397).
    • Febrile morbidity incidence was 23.5% with cefonicid vs. 15.5% with cefoxitin (P > .25).
    • No statistically significant differences were observed between the two antibiotic regimens.

    Conclusions:

    • Both cefonicid and cefoxitin demonstrate comparable efficacy in preventing postpartum infections following cesarean delivery.
    • Cefonicid offers a potentially more cost-effective option due to its dosing schedule and lower price.
    • Further economic analysis may support cefonicid as a preferred agent for cesarean prophylaxis.