The effect of pregnancy on disease development and mortality in B/W F1 mice

Pregnancy was encouraged in 15 B/W mice (Group 1) and the rate of development of FANA, anti-DNA antibodies, and proteinuria compared with that seen in 15 control mice (Group 2). The mean number of pregnancies for Group 1 mice was 5.2. No difference was seen in mortality rate or in the onset of serologic or urinary abnormalities between the 2 groups.