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Hsa-miR-330-5p Aggravates Thyroid Carcinoma via Targeting FOXE1

Yuxia Wang1, Zhaozhe Liu2, Xiangning Ren1

  • 1Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.

Journal of Oncology
|July 26, 2021
PubMed
Abstract

Insights

MicroRNA miR-330-5p is upregulated in thyroid carcinoma (TC), promoting cancer progression by targeting FOXE1. Inhibiting miR-330-5p may offer new therapeutic strategies for TC patients.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Thyroid carcinoma (TC) is a common endocrine malignancy.
  • Aberrant microRNA (miRNA) expression is implicated in TC development and progression.
  • The specific role of miR-330-5p in TC progression was previously unknown.

Purpose of the Study:

  • To investigate the expression and function of miR-330-5p in thyroid carcinoma.
  • To determine the diagnostic and prognostic value of miR-330-5p in TC.
  • To elucidate the molecular mechanism underlying miR-330-5p's role in TC progression.

Main Methods:

  • Analysis of miR-330-5p expression levels in TC tissues and cell lines compared to controls.
  • Functional assays to assess the impact of miR-330-5p downregulation on TC cell proliferation, migration, and invasion.
  • Investigation of miR-330-5p's interaction with forkhead box E1 (FOXE1) and rescue experiments.

Main Results:

  • miR-330-5p was significantly upregulated in TC tissues and cell lines.
  • Downregulation of miR-330-5p inhibited TC cell proliferation, migration, and invasion.
  • miR-330-5p was found to negatively regulate FOXE1 expression, and FOXE1 overexpression counteracted miR-330-5p's pro-tumor effects.

Conclusions:

  • miR-330-5p promotes thyroid carcinoma progression by targeting FOXE1.
  • This finding suggests that miR-330-5p could be a potential therapeutic target for TC.
  • Targeting the miR-330-5p/FOXE1 axis may offer novel treatment strategies for thyroid carcinoma.

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