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Related Concept Videos

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Related Experiment Video

Updated: Oct 26, 2025

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
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Circular RNA Expression: Its Potential Regulation and Function in Abdominal Aortic Aneurysms.

Yanshuo Han1, Hao Zhang1, Ce Bian2

  • 1School of Life and Pharmaceutical Science, Dalian University of Technology, Dalian, China.

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Circular RNAs (circRNAs) play a role in abdominal aortic aneurysms (AAAs). Understanding circRNA mechanisms offers potential for AAA diagnosis and prevention.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Abdominal aortic aneurysms (AAAs) are life-threatening vascular conditions.
  • Circular RNAs (circRNAs) are increasingly recognized for their role in disease pathogenesis.
  • circRNAs are stable, single-stranded RNAs with regulatory functions.

Purpose of the Study:

  • To comprehensively review the biosynthesis, bibliometrics, and mechanisms of circRNAs in AAA development.
  • To elucidate the molecular mechanisms underlying circRNA involvement in AAA pathogenesis.
  • To examine the diagnostic potential of circRNAs for AAAs.

Main Methods:

  • Literature review and bibliometric analysis of studies on circRNAs and AAAs.
  • Examination of circRNA roles in modulating endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs).
  • Analysis of circRNA regulatory pathways in AAA development.

Main Results:

  • circRNAs are implicated in the pathogenesis of AAAs.
  • circRNAs function as molecular sponges regulating transcription.
  • Evidence suggests circRNAs impact ECs, macrophages, and VSMCs in AAA development.

Conclusions:

  • circRNAs hold significant potential for the diagnosis and prevention of AAAs in clinical practice.
  • Further research into circRNA regulatory pathways is crucial for understanding AAA etiology.
  • circRNAs represent promising biomarkers and therapeutic targets for AAAs.