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Updated: Oct 26, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Atypical erythema annulare centrifugum in a child with celiac disease
Martina Votto1, Maria De Filippo1, Amelia Licari1
1Department of Pediatrics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy.
Insights
Dermatitis herpetiformis is a well-known skin manifestation of celiac disease (CD). Other chronic skin conditions may also indicate CD and warrant consideration in diagnosis.
Area of Science:
- Gastroenterology and Dermatology
Background:
- Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
- Extraintestinal manifestations (EIMs) are common in CD, affecting various organ systems.
Observation:
- Dermatitis herpetiformis (DH) is the most recognized skin manifestation of CD.
- Other chronic skin conditions have been anecdotally linked to CD.
Findings:
- While DH is the classic association, a broader spectrum of chronic skin lesions may be linked to celiac disease.
- These diverse dermatoses should be evaluated for potential underlying CD.
Implications:
- Expanding the differential diagnosis of chronic skin conditions to include celiac disease can improve diagnostic rates.
- Early identification of CD through dermatological assessment can prevent long-term complications.
Abstract:
Herpetiformis dermatitis is the best characterized extraintestinal manifestation of celiac disease (CD). However, other chronic heterogeneous skin lesions have been associated with CD and should be considered in the differential diagnosis.
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