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Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
Steve Biko Otieno1,2,3, Alaa Altahan1,2,3, Fnu Kaweeta1
1The University of Tennessee Health Science Center, Department of Hematology and Oncology, 19 S. Manassas, Memphis, TN 38103, USA.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.
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