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Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
Si Li1, Nishant Sharma1, Daniel Kazmierski1
1Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, USA.
Abstract:
Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by the COVID-19 pandemic. We report a case of a patient with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage (DAH) following treatment with avelumab.
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