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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

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Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
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Stem Cell Therapies for Progressive Multiple Sclerosis.

Jayden A Smith1, Alexandra M Nicaise2, Rosana-Bristena Ionescu2

  • 1Cambridge Innovation Technologies Consulting (CITC) Limited, Cambridge, United Kingdom.

Frontiers in Cell and Developmental Biology
|July 26, 2021
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for progressive multiple sclerosis (PMS) by offering neurotrophic support, immunomodulation, and cell replacement. Further research is needed to overcome challenges in translating these regenerative medicine approaches into effective treatments.

Keywords:
clinical trialmesenchymal stem cellneural stem cellprogressive multiple sclerosisregenerative neuroimmunologystem cell therapy

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Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease causing demyelination and axonal degeneration.
  • Relapsing-remitting MS (RRMS) has treatments, but most patients progress to irreversible disability in progressive MS (PMS).
  • Current PMS treatments are limited, lacking efficacy in slowing degeneration or promoting repair.

Purpose of the Study:

  • To explore the potential of stem cell therapies for treating progressive multiple sclerosis (PMS).
  • To review preclinical and clinical evidence supporting stem cells in PMS treatment.
  • To discuss challenges in translating stem cell therapies into clinical practice for PMS.

Main Methods:

  • Review of preclinical research on stem cell therapy for neurodegenerative diseases.
  • Analysis of clinical trial data for stem cell interventions in multiple sclerosis.
  • Discussion of the biological mechanisms of stem cells, including neurotrophic support, immunomodulation, and cell replacement.

Main Results:

  • Stem cell transplantation demonstrates multifactorial therapeutic benefits for chronic neuroinflammation.
  • Evidence suggests potential for stem cells to provide neurotrophic support, modulate immune responses, and replace damaged cells.
  • Current therapeutic options for PMS are limited, highlighting the need for novel approaches.

Conclusions:

  • Stem cell therapies hold significant promise for addressing the unmet needs in progressive multiple sclerosis treatment.
  • Further research and clinical trials are essential to overcome hurdles in the clinical translation of stem cell therapies for PMS.
  • Stem cell transplantation may offer a revolutionary regenerative medicine approach for managing progressive neuroinflammation in MS.