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Updated: Oct 26, 2025
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
COVID-19 and gastroenteric manifestations
Zhang-Ren Chen1, Jing Liu1, Zhi-Guo Liao1
1Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330100, Jiangxi Province, China.
Coronavirus disease 2019 (COVID-19) impacts the respiratory and gastrointestinal systems. This review details COVID-19
Area of Science:
- Gastroenterology and Virology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
- SARS-CoV-2 primarily affects the respiratory system but also targets gastrointestinal epithelial cells via the ACE2 receptor.
- Gastrointestinal symptoms and potential fecal-oral transmission are significant manifestations of COVID-19.
Purpose of the Study:
- To provide an updated review of COVID-19-associated gastrointestinal manifestations.
- To consolidate information on clinical features, basic research, and clinical practices related to gastrointestinal involvement in COVID-19.
Main Methods:
- This study is a review of existing literature.
- It synthesizes findings from clinical observations and basic scientific research.
Main Results:
- COVID-19 infection leads to gastrointestinal symptoms due to direct viral attack on gut cells.
- Adverse drug reactions from COVID-19 treatments can also cause gastrointestinal issues.
- The review covers clinical presentations, underlying mechanisms, and management strategies.
Conclusions:
- Gastrointestinal manifestations are a notable aspect of COVID-19, requiring clinical attention.
- Understanding these symptoms is crucial for comprehensive patient care during the pandemic.
- Further research and clinical practice updates are necessary to address these manifestations effectively.
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