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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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Published on: September 21, 2017

RNA and DNA nanoparticles for triggering RNA interference

Ziad El Tannir¹, Kirill A Afonin^1,2, Bruce A Shapiro²

¹Department of Chemistry, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, North Carolina 28223, USA.

RNA & Disease (Houston, Tex.)

|July 26, 2021

Abstract

None:

Control over the delivery of different functionalities and their synchronized activation in vivo is a challenging undertaking that requires careful design and implementation. The goal of the research highlighted herein was to develop a platform allowing the simultaneous activation of multiple RNA interference pathways and other functionalities inside cells. Our team has developed several RNA, RNA/DNA and DNA/RNA nanoparticles able to successfully complete such tasks. The reported designs can potentially be used to target myriad of different diseases.

Keywords:

FRET RNA interference RNA nanotechnology RNA/DNA hybrids siRNAs

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