Epithelial-Mesenchymal Transition in Atopy: A Mini-Review

Area of Science:

• Immunology and Dermatology
• Cell Biology and Tissue Repair

Background:

• Atopic diseases, including atopic dermatitis (AD), asthma, and allergic rhinitis (AR), share inflammatory and barrier dysfunction pathways.
• Epithelial to mesenchymal transition (EMT) is crucial for tissue repair and involves inflammatory signaling, with established links to asthma and AR.

Purpose of the Study:

• To review the current literature on the role of epithelial to mesenchymal transition (EMT) in atopic dermatitis (AD).
• To explore the connection between EMT-related barrier dysfunction and atopic diseases.
• To identify potential therapeutic targets and implications for AD treatment.

Main Methods:

• Mini-review of existing scientific literature.
• Analysis of studies focusing on EMT, barrier dysfunction, and atopic diseases.
• Emphasis on animal models, ex vivo cell cultures, and tissue biopsies.

Main Results:

• The link between EMT and AD is less understood compared to asthma and AR.
• EMT-related barrier dysfunction may contribute to AD development and other atopic conditions.
• Current research predominantly relies on non-human models.

Conclusions:

• EMT represents a potential therapeutic target for atopic dermatitis.
• Findings suggest implications for topical steroid use and environmental exposure assessments in AD management.
• Further in vivo research is essential to advance understanding and clinical translation for patient benefit.