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Updated: Oct 26, 2025
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Hemiplegic migraine episode triggered by regadenoson
Mohammed Elsadany1, Sean R McMahon1, Sandhya Mehla2
1Division of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.
Summary
Regadenoson, a common vasodilator for myocardial perfusion imaging, rarely causes neurological issues. In a patient with a history of hemiplegic migraine, regadenoson triggered a similar episode, suggesting caution in similar cases.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Myocardial perfusion imaging (MPI) using SPECT and PET is crucial for diagnosing coronary artery disease.
- Regadenoson, a selective A2A adenosine receptor agonist, is a widely used vasodilator for stress MPI due to its safety and ease of use.
- While generally safe, regadenoson can cause adverse reactions, including rare neurological events like seizures and stroke.
Purpose of the Study:
- To report a rare neurological adverse event associated with regadenoson administration during PET MPI.
- To highlight a potential trigger for hemiplegic migraine in a patient with a history of the condition.
Main Methods:
- A case report detailing a patient's experience during a PET MPI study.
- Review of the patient's medical history, symptoms, and diagnostic work-up.
- Analysis of the potential pharmacological mechanisms of regadenoson's adverse effects.
Main Results:
- A patient with a history of hemiplegic migraine experienced left-sided weakness and headache after regadenoson administration.
- Cerebrovascular accident imaging was normal, and symptoms resolved within 24 hours.
- The event was concluded to be a regadenoson-induced hemiplegic migraine episode.
Conclusions:
- Regadenoson may trigger hemiplegic migraine in susceptible individuals.
- Caution is advised when using regadenoson or adenosine in patients with a history of hemiplegic migraine.
- Further investigation into the neurological effects of A2A adenosine receptor agonists is warranted.
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