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Related Experiment Video

Updated: Oct 26, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Long-term retinal changes in progressive geographic atrophy.

Denise Gallagher¹, Gagan Kalra², Mohammed Abdul Rasheed³

¹UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.

European Journal of Ophthalmology

|July 26, 2021

Summary

Progressive age-related macular degeneration (AMD) with geographic atrophy (GA) causes significant changes in outer retinal layers, particularly the outer nuclear and outer segment layers. These changes strongly correlate with the retinal pigment epithelium layer

Keywords:

Retinal thickness assessment geographic atrophy long-term retinal thickness changes progressive retinal atrophy

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Published on: November 6, 2017

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Last Updated: Oct 26, 2025

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Published on: May 26, 2023

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Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Area of Science:

Ophthalmology
Retinal Imaging
Macular Degeneration Research

Background:

Age-related macular degeneration (AMD) is a primary cause of vision loss.
Progressive non-exudative AMD with geographic atrophy (GA) leads to retinal layer deterioration over time.

Purpose of the Study:

To evaluate retinal layer changes in eyes with progressive non-exudative AMD and GA.
To correlate changes in the retinal pigment epithelium (RPE) layer with other retinal layers and GA progression.

Main Methods:

Retrospective analysis of spectral domain optical coherence tomography (SD-OCT) scans from patients with GA and at least 4 years of follow-up.
Semi-automated segmentation algorithm used to measure retinal layer thickness.
Regression analysis to assess correlations between RPE thickness changes and other retinal layers, as well as GA length.

Main Results:

Statistically significant variations observed in the outer nuclear layer (ONL), outer segment layers (OSL), and retinal pigment epithelium (RPE) thickness between baseline and final visits.
Changes in ONL and OSL thickness showed a significant correlation with changes in RPE thickness (r=0.72 and r=0.93, respectively).
Other retinal layers did not show a significant correlation with RPE thickness changes.

Conclusions:

Outer retinal layers (ONL and OSL) exhibit significant and widespread thickness changes in eyes with GA due to AMD.
These outer retinal layer changes are most significantly correlated with RPE thickness alterations.
Measuring retinal layer bands can serve as valuable surrogate quantitative parameters for studying GA in AMD.