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Response to intraperitoneal Staphylococcus epidermidis challenge in renal failure mice
B Gallimore1, R F Gagnon, G K Richards
1Department of Medicine, Montreal General Hospital, McGill University, Quebec, Canada.
Kidney International
|November 1, 1987
Summary
Renal failure significantly delays Staphylococcus epidermidis clearance and diminishes the inflammatory response in peritonitis, impacting end-stage renal disease patients undergoing continuous ambulatory peritoneal dialysis.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- End-stage renal disease (ESRD) patients on continuous ambulatory peritoneal dialysis (CAPD) are susceptible to Staphylococcus epidermidis peritonitis.
- Renal failure's impact on the pathogenesis of S. epidermidis peritonitis requires further elucidation.
Purpose of the Study:
- To investigate the role of renal failure in the pathogenesis of S. epidermidis peritonitis in a mouse model.
- To assess bacterial clearance and inflammatory responses in mice with surgically-induced renal failure.
Main Methods:
- Surgically-induced renal failure in mice, followed by intraperitoneal (i.p.) inoculation of S. epidermidis.
- Assessment of bacterial clearance and peritoneal inflammatory response over 72 hours.
- Comparison between renal failure mice, sham-operated controls, and normal controls.
Main Results:
- Peritoneal clearance of S. epidermidis was significantly delayed in renal failure mice.
- Viable bacteria persisted in the peritoneum even after negative peritoneal washings.
- Peritoneal inflammatory response, particularly polymorphonuclear cell influx, was markedly diminished in renal failure mice.
Conclusions:
- Renal failure impairs the local peritoneal inflammatory response and delays bacterial clearance in S. epidermidis peritonitis.
- The precise factors contributing to this impairment in renal failure mice need further investigation.