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Updated: Oct 26, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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MUSTARD-a comprehensive resource of mutation-specific therapies in cancer

Gauri Mittal1, Anu R I2,3, Aastha Vatsyayan4,5

  • 1Indraprastha Institute of Information Technology, Okhla Industrial Estate, Phase III, Delhi 110020, India.

Database : the Journal of Biological Databases and Curation
|July 26, 2021
PubMed

Insights

The Mutation-Specific Therapies Resource and Database in Cancer (MUSTARD) centralizes information on targeted cancer therapies, mutations, and outcomes. This resource aids clinicians, patients, and researchers in accessing crucial data for cancer treatment decisions.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • The global cancer burden necessitates advanced treatment strategies.
  • Targeted therapies offer efficacy against cancer cells with actionable mutations, minimizing side effects.
  • Rapidly evolving drug development requires swift dissemination of information to stakeholders.

Purpose of the Study:

  • To develop a centralized, structured, and well-annotated resource for mutation-specific cancer therapies.
  • To facilitate access to diverse information including cancer subtypes, mutations, therapies, and outcomes.
  • To augment the clinical impact of targeted cancer therapies.

Main Methods:

  • Development of the Mutation-Specific Therapies Resource and Database in Cancer (MUSTARD).
  • Curation and annotation of data from scientific publications.
  • Integration of information on cancer subtypes, gene mutations, drug therapies, and observed effects.

Main Results:

  • MUSTARD currently contains over 2105 unique entries.
  • The database links 418 drug therapies, 189 cancer subtypes, and 167 genes.
  • Data is curated from 862 publications, providing comprehensive annotations.

Conclusions:

  • MUSTARD serves as a unique, centralized resource for mutation-specific, gene fusion, and overexpressed gene-targeted cancer therapies.
  • The database enhances accessibility of critical information for cancer research and clinical practice.
  • MUSTARD supports informed decision-making in personalized cancer treatment.

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