Related Experiment Video
Updated: Oct 26, 2025
05:23
Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
4.1K
Gene polymorphism association studies in cluster headache: A field synopsis and systematic meta-analyses
Sarah Cargnin1, Grazia Sances2, Jae Il Shin3
1Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale "A. Avogadro", Novara, Italy.
Headache
|July 26, 2021
Summary
This study found no significant genetic associations for cluster headache (CH) susceptibility or triptan response. Further large-scale studies are needed to identify reliable genetic variants for CH.
Area of Science:
- Neuroscience
- Genetics
- Pharmacogenomics
Background:
- Cluster headache (CH) susceptibility and treatment response have been investigated for genetic determinants, but findings are often conflicting.
- A comprehensive quantitative summary of evidence in this field is lacking.
- Previous genetic studies on CH have yielded inconsistent results, necessitating a systematic review and meta-analysis.
Purpose of the Study:
- To systematically review and quantitatively summarize the evidence for genetic determinants of cluster headache (CH) susceptibility and treatment response.
- To identify reliable genetic variants associated with CH risk and response to triptan therapy.
- To provide a quantitative assessment of the genetic associations reported in the literature.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Web of Knowledge, Cochrane Library, OpenGrey) up to December 2020.
- Meta-analyses were performed for gene polymorphisms investigated in at least two studies.
- The Bayesian false discovery probability (BFDP) test was used to assess the credibility of observed genetic associations.
Main Results:
- Out of 27 identified articles, 17 studies evaluating 12 single nucleotide polymorphisms (SNPs) were included in the quantitative analysis.
- No significant association with CH risk was found for 10 SNPs, including several in HCRTR2, ADH4, and CLOCK.
- While HCRTR2 rs9357855 and GNB3 rs5443 showed potential associations with CH risk and triptan response, respectively, the BFDP values indicated a lack of noteworthy results.
Conclusions:
- Current evidence does not support significant associations between the investigated SNPs and cluster headache (CH) susceptibility or treatment response.
- Well-designed genome-wide association studies (GWASs) and large replication studies are crucial for identifying reliable genetic variants in CH.
- Further research is needed to elucidate the genetic underpinnings of CH and guide personalized treatment strategies.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.8K
01:05Single Nucleotide Polymorphisms-SNPs
17.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.0K
01:28Human Genetics
905
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
905