Pancreatic bicarbonate response to a meal

In dogs with gastric and pancreatic fistulas, the rate of delivery of acid from the stomach to the duodenum and the rate of pancreatic bicarbonate secretion were measured in response to a meal of liver extract. The time course of changes in quantity of bicarbonate secreted per minute closely paralleled that of changes in quantity of hydrogen ions delivered to the duodenum per minute. For each mole of hydrogen ion entering the duodenum, about 5 moles of bicarbonate were secreted.