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Related Experiment Video

Updated: Oct 26, 2025

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3D Bioprinted Multicellular Vascular Models.

Karli A Gold1, Biswajit Saha1, Navaneeth Krishna Rajeeva Pandian1

  • 1Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, 77843, USA.

Advanced Healthcare Materials
|July 26, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel nanoengineered bioink for 3D bioprinting. This advanced bioink enables the creation of stable, anatomically accurate blood vessels for disease modeling and drug testing.

Keywords:
3D bioprintingcell-laden bioinkdisease modelsregenerative medicinevascular tissue

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Current limitations in 3D bioprinting bioinks hinder translation to clinical applications.
  • Existing cell-laden bioinks often lack adequate biocompatibility, printability, and structural integrity.
  • There is a need for advanced bioinks that can accurately mimic native tissue microenvironments.

Purpose of the Study:

  • To introduce a new class of nanoengineered hydrogel-based bioinks for 3D bioprinting.
  • To fabricate 3D, anatomically accurate, multicellular blood vessels.
  • To create a model for studying vascular disease pathophysiology and evaluating therapeutics.

Main Methods:

  • Development of a nanoengineered hydrogel-based bioink.
  • 3D printing of multicellular blood vessel constructs using the developed bioink.
  • Co-culture of endothelial cells and vascular smooth muscle cells within the printed vessels.
  • Assessment of cell viability, phenotype, printability, and structural stability.
  • Evaluation of the 3D bioprinted vessel's response to cytokine stimulation and blood perfusion.

Main Results:

  • The nanoengineered bioink demonstrated high printability and protected encapsulated cells from shear forces.
  • 3D bioprinted cells maintained viability and a healthy phenotype for nearly one month.
  • The 3D bioprinted blood vessels successfully recapitulated thromboinflammatory responses upon stimulation and perfusion.
  • The constructs mimicked both physical and chemical microenvironments of native human vasculature.

Conclusions:

  • The developed nanoengineered bioink is suitable for fabricating functional 3D vascular constructs.
  • This 3D bioprinted vessel model offers a promising platform for vascular disease research.
  • The model can be utilized for preclinical assessment of therapeutics, toxins, and other chemicals.