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Updated: Oct 26, 2025
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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality : A Prospective Cohort
Mahdi Sheikh1, Anush Mukeriya2, Oxana Shangina2
1International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France (M.S., P.B.).
Annals of Internal Medicine
|July 26, 2021
Summary
Quitting smoking after a lung cancer diagnosis significantly improves survival rates and reduces disease progression. This finding applies to all smokers, regardless of intensity or cancer stage.
Area of Science:
- Oncology
- Public Health
- Smoking Cessation Research
Background:
- Lung cancer is a leading global cause of cancer death.
- Approximately 50% of lung cancer patients are active smokers at diagnosis.
Purpose of the Study:
- To investigate the impact of smoking cessation after lung cancer diagnosis on disease progression and mortality.
- To assess survival outcomes and mortality risks in lung cancer patients who quit smoking versus those who continue.
Main Methods:
- A prospective study involving 517 current smokers diagnosed with early-stage non-small cell lung cancer (NSCLC).
- Patients were recruited between 2007 and 2016 and followed annually through 2020.
- Outcomes measured included overall survival, progression-free survival, and cancer-specific mortality, with hazard ratios calculated.
Main Results:
- Smoking cessation was associated with a significantly longer median overall survival (6.6 vs. 4.8 years).
- Patients who quit smoking demonstrated higher 5-year overall survival (60.6% vs. 48.6%) and progression-free survival (54.4% vs. 43.8%).
- Smoking cessation reduced the risk of all-cause mortality (HR, 0.67), cancer-specific mortality (HR, 0.75), and disease progression (HR, 0.70).
Conclusions:
- Smoking cessation after diagnosis materially improves overall and progression-free survival in early-stage lung cancer patients.
- The benefits of quitting smoking were consistent across different smoking intensities and cancer stages.
- Encouraging smoking cessation in lung cancer patients is crucial for improving treatment outcomes.
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