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Updated: Oct 26, 2025
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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
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New horizons in early drugs development in solid cancers.
Nuria Kotecki1, Nadège Kindt2, Mohammad Krayem2
1Oncology Medicine Department.
Current Opinion in Oncology
|July 26, 2021
Summary
Emerging preclinical models enhance the selection of anticancer drugs. Advances in oncology are driving the development of novel immunotherapies and targeted therapies for improved cancer treatment.
Area of Science:
- Oncology
- Drug Development
- Preclinical Research
Background:
- Drug development progresses from basic research to clinical application, with each stage being critical.
- Understanding cancer biology and precision oncology fuels the development of novel anticancer agents.
Purpose of the Study:
- To review emerging preclinical models for cancer drug development.
- To provide an overview of recently developed oncology drugs.
Main Methods:
- Utilizing advanced preclinical models such as those replicating immune-tumor interactions.
- Employing 3D cell cultures and microfluidic platforms to study cancer biology.
- Analyzing the interplay between cancer and stromal cells.
Main Results:
- Preclinical models are crucial for developing immunotherapies and combination therapies.
- New drugs, including antibody-drug conjugates (ADCs), immunotherapies, and molecular-targeted therapies, are advancing in clinical research.
- Improved preclinical models facilitate accurate selection of drug candidates.
Conclusions:
- Enhanced preclinical models will improve the selection of drug candidates for clinical trials.
- Innovative oncology drugs are progressing through development phases.
- A patient-centered clinical research model is needed for faster access to innovations and targeted trials.
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