Related Experiment Video
Updated: Oct 26, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Recent therapeutic targets in diabetic nephropathy
Marwa Mohsen1, Ahmed A Elberry2, Alaa Mohamed Rabea3
1Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Diabetic kidney disease is a growing concern. Emerging treatments like dipeptidyl peptidase IV (DPP-4) inhibitors show promise for managing this complication beyond blood sugar control.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetes mellitus prevalence is rising globally.
- Diabetic kidney disease is a major complication, leading to end-stage renal disease.
- Cardiovascular diseases are also linked to diabetes.
Purpose of the Study:
- To review the pathophysiology of diabetic nephropathy.
- To explore new therapeutic agents for diabetic kidney disease management.
- To focus on the role of dipeptidyl peptidase IV (DPP-4) inhibitors.
Main Methods:
- Literature review using PubMed, Scopus, Google Scholar, and open-access engines.
- Analysis of articles on diabetic nephropathy pathophysiology and treatment.
- Evaluation of emerging agents for nephroprotection.
Main Results:
- Current recommendations focus on glycemic and blood pressure control, plus renin-angiotensin system blockade.
- Agents with nephroprotective effects beyond glycemic control are clinically evidenced.
- Dipeptidyl peptidase IV (DPP-4) inhibitors demonstrate clinical utility.
Conclusions:
- Diabetic nephropathy's pathophysiology, manifestations, and treatments are discussed.
- The clinical role and nephroprotective effects of DPP-4 inhibitors are detailed.
- Emerging therapies offer new avenues for managing diabetic kidney disease.
More Related Videos
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
07:15Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Related Concept Videos
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Direct Renin Inhibitors
Antihypertensive Drugs: Action of Diuretics