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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Updated: Oct 26, 2025

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
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Prenatal methylmercury exposure is associated with decrease heart rate variability in children.

Peggy Hiu Ying Chan1, Ka Ming Kwok2, Michael Ho Ming Chan3

  • 1Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Brain and Mind Institute, The Chinese University of Hong Kong, Hong Kong.

Environmental Research
|July 26, 2021
PubMed
Summary
This summary is machine-generated.

Prenatal methylmercury (MeHg) exposure in children is linked to reduced cardiac autonomic function, specifically decreased parasympathetic activity. This finding highlights potential cardiovascular risks even at low environmental mercury exposure levels.

Keywords:
Blood pressureCardiac autonomicCardiotoxicityHeart rate variabilityMethylmercury

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Area of Science:

  • Environmental Health
  • Pediatric Cardiology
  • Toxicology

Background:

  • Epidemiological studies suggest mercury (Hg) may cause cardiotoxicity.
  • The impact of Hg on children's cardiac autonomic activity and blood pressure at EPA reference dose levels is unknown.

Purpose of the Study:

  • Investigate the association between low-dose prenatal and recent methylmercury (MeHg) exposures and cardiac autonomic function and blood pressure in children.
  • Adjust for factors like fish consumption in a high fish consumption coastal city population.

Main Methods:

  • Recruited 604 children aged 7-8 years from a previous birth cohort.
  • Measured heart rate variability (HRV), resting heart rate (RHR), and blood pressure as markers of cardiac autonomic function.
  • Assessed prenatal (cord blood) and recent (whole blood) MeHg exposure and recent fish consumption.

Main Results:

  • Prenatal MeHg exposure correlated with decreased HRV, indicating reduced parasympathetic activity and a shift towards sympathetic predominance.
  • Low-dose prenatal MeHg exposure was associated with adverse cardiac autonomic modulation.
  • Adjusting for fish consumption amplified the adverse associations of MeHg.

Conclusions:

  • Prenatal methylmercury (MeHg) exposure is associated with decreased parasympathetic modulation of cardiac autonomic function in children.
  • Low-level environmental mercury exposure may pose risks to pediatric cardiovascular health.