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Related Experiment Video

Updated: Oct 26, 2025

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion

Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion

Published on: February 14, 2025

Bariatric Surgery-Associated Myelopathy.

Sewar Asakly¹, Ramit Magen-Rimon¹, Ahmad Ighbariya¹

¹Department of Pediatrics, Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel.

|July 26, 2021

Summary

Postbariatric myelopathy is a rare complication following bariatric surgery. Patients experiencing neurological symptoms post-surgery should be evaluated for this condition due to potential immunomodulatory changes.

Keywords:

Bariatric surgery Myelopathy Nutritional deficiencies

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Area of Science:

Immunology
Neurology
Gastroenterology

Background:

Bariatric surgery is an effective treatment for morbid obesity in adults and adolescents.
The post-surgical period can lead to nutritional deficiencies, hormonal shifts, and altered gut microbiome.
These factors can create an immunomodulatory imbalance and a proinflammatory state.

Observation:

Changes post-bariatric surgery may affect T cell activity and neural barrier permeability.
Gut dysbiosis and increased intestinal permeability are observed.
A shift towards a proinflammatory metabolic profile can occur.

Findings:

These alterations may precipitate myelopathy, particularly multiple sclerosis (MS), in susceptible individuals.
Postbariatric myelopathy is a rare but significant neurological complication.
Genetic predisposition and other risk factors increase the likelihood of developing myelopathy.

Implications:

Clinicians should consider postbariatric myelopathy in patients presenting with relevant neurological symptoms after surgery.
Early recognition and management are crucial for affected individuals.
Further research into the mechanisms linking bariatric surgery to neurological conditions is warranted.