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Emerging impact of quercetin in the treatment of prostate cancer

Soudeh Ghafouri-Fard1, Farnaz Aghazadeh Shabestari2, Saba Vaezi3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 27, 2021
PubMed

Insights

Quercetin, a plant flavonoid, shows promise in preventing and treating prostate cancer by inducing cancer cell death and enhancing other therapies. It selectively targets neoplastic cells, offering a potential new avenue for prostate cancer management.

Area of Science:

  • * Phytochemistry and Cancer Biology
  • * Nutritional Oncology

Background:

  • * Quercetin, a flavonoid found in fruits and vegetables, possesses anti-inflammatory, antioxidant, and anticancer properties.
  • * It exhibits potential in suppressing cell cycle progression and inducing apoptosis in neoplastic cells, particularly relevant to prostate cancer.
  • * Quercetin may play a role in preventing prostate cancer by inhibiting key genes like the androgen receptor (AR) and prostate specific antigen (PSA).

Purpose of the Study:

  • * To review current research on the preventive and therapeutic applications of quercetin in prostate cancer.
  • * To highlight quercetin's selective cytotoxic effects on cancerous prostate cells compared to normal cells.
  • * To explore quercetin's mechanisms of action, including apoptosis induction and potential synergy with other treatments.

Main Methods:

  • * Review of in vitro and in vivo experimental data on quercetin's effects on prostate cancer.
  • * Analysis of studies investigating quercetin's impact on cell cycle regulation and apoptosis pathways.
  • * Examination of research on quercetin's interaction with prostate cancer-related genes and therapeutic agents.

Main Results:

  • * Quercetin demonstrates differential effects on normal versus neoplastic prostate cells, indicating specific cytotoxicity against cancer cells.
  • * Its mechanism involves the modulation of apoptosis-related proteins (Bax, Bcl-xL) and the activation of caspase cascades.
  • * Quercetin may enhance the efficacy of other prostate cancer treatments, such as TNF-related apoptosis-inducing ligand (TRAIL).

Conclusions:

  • * Quercetin exhibits significant potential as both a preventive and therapeutic agent for prostate cancer.
  • * Its ability to induce apoptosis and selectively target cancer cells warrants further investigation.
  • * Combination therapies involving quercetin may offer novel strategies to overcome treatment resistance in prostate cancer.
Keywords:
Prostate cancerQuercetin

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