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Published on: February 3, 2017
New cytochalasans from an endophytic Xylaria species associated with Costa Rican Palicourea elata (Rubiaceae)
Wolfgang Hinterdobler1,2, Markus Bacher3, Bao-Bao Shi4
1Department of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.
Abstract:
Four new leucine-derived cytochalasans, possessing a 5,6,5,8-ring (1) and a 5,6,11-ring core (2-4), were isolated from a cultivated endophytic fungus Xylaria sp. strain WH2D4 (Xylariaceae). This fungus was isolated from leaves of the neotropical tree species Palicourea elata (Sw.) Borhidi (Rubiaceae) collected in Costa Rica. The chemical structures were determined by employing IR, MS as well as 1D- and 2D-NMR experiments. The stereochemistry at C-15 of compound 4 was determined by quantum calculations. The isolated compounds did not affect germination and growth of Trichoderma reesei and the opportunistic human fungal pathogen T. longibrachiatum.
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