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We need to bring R0 < 1 to treat cancer too

Devabhaktuni Srikrishna1, Kris Sachsenmeier2

  • 1Breakbio Corp., 63 Bovet Road, #418, San Mateo, CA, 94402, USA. sri.devabhaktuni@gmail.com.

Genome Medicine
|July 27, 2021
PubMed

Insights

Tumor growth depends on cancer cell proliferation. Combining immunotherapies with other treatments may control microsatellite stable metastatic colorectal cancer (MSS-mCRC) by slowing cancer growth and boosting immune cell killing.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Biology

Background:

  • Tumor growth and metastasis are driven by cancer cell proliferation.
  • Microsatellite stable metastatic colorectal cancer (MSS-mCRC) remains a therapeutic challenge.
  • Current treatment strategies aim to inhibit cancer cell growth and enhance anti-tumor immunity.

Purpose of the Study:

  • To review recent clinical findings in MSS-mCRC.
  • To explore the potential of combination therapies in controlling MSS-mCRC.
  • To identify strategies that synergistically impact cancer cell growth and immune response.

Main Methods:

  • Literature review of recent clinical results in MSS-mCRC.
  • Analysis of treatment combinations including immunotherapy, vaccines, checkpoint inhibitors, targeted therapies, multikinase inhibitors, chemotherapy, and radiation.
  • Evaluation of effects on cancer cell growth rate and T cell killing rate.

Main Results:

  • Recent clinical results suggest potential for immunotherapy combinations in MSS-mCRC.
  • Simultaneous slowing of cancer cell growth and enhancement of T cell killing are key objectives.
  • Combination therapies show promise in synergizing to control MSS-mCRC.

Conclusions:

  • Immunotherapy combinations hold future promise for MSS-mCRC treatment.
  • Targeting both cancer cell proliferation and immune-mediated killing is a viable strategy.
  • Synergistic effects of combined treatments may lead to disease control in MSS-mCRC.

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