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Human Papillomavirus-Associated Head and Neck Cancer.

Juan C Nogues1, Scott Fassas2, Collin Mulcahy2

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Journal of the American Board of Family Medicine : JABFM
|July 27, 2021
PubMed
Summary
This summary is machine-generated.

Human papillomavirus (HPV) now causes more oropharyngeal squamous cell carcinoma (OPSCC) than any other HPV-related cancer. Primary care providers are key to preventing and diagnosing HPV-positive OPSCC due to low awareness and vaccination rates.

Keywords:
ImmunizationOtolaryngologyPapillomavirus VaccinesPatient Care TeamPrimary Health CareSexually Transmitted DiseasesSquamous Cell Carcinoma of Head and Neck

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Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Oropharyngeal squamous cell carcinoma (OPSCC) incidence declined with reduced smoking but is now rising due to human papillomavirus (HPV).
  • HPV-positive OPSCC is now the leading cause of HPV-related cancers in the U.S., surpassing cervical cancer.
  • Significant gaps exist in public awareness regarding the HPV-OPSCC link and low HPV vaccination rates.

Purpose of the Study:

  • To review the epidemiology, screening, diagnosis, prognosis, and prevention of HPV-positive OPSCC.
  • To emphasize the critical role of primary care providers in managing HPV-positive OPSCC.
  • To address the deficit in awareness and low vaccination rates impacting HPV-positive OPSCC.

Main Methods:

  • Literature review focusing on HPV-positive OPSCC.
  • Analysis of epidemiological trends and clinical characteristics.
  • Examination of prevention strategies and the role of primary care.

Main Results:

  • HPV-positive OPSCC presents distinct epidemiological and prognostic features compared to HPV-negative disease.
  • Primary care providers are uniquely positioned for early detection and prevention efforts.
  • Low awareness and vaccination rates necessitate increased provider and public education.

Conclusions:

  • HPV-positive OPSCC is a growing public health concern requiring targeted prevention and early diagnosis strategies.
  • Enhanced primary care provider involvement is crucial for combating the rise of HPV-positive OPSCC.
  • Public health initiatives must address awareness gaps and promote HPV vaccination to reduce the burden of HPV-related cancers.