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The ribosome epitranscriptome: inert-or a platform for functional plasticity?

Joseph Georgeson1, Schraga Schwartz1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.

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|July 27, 2021
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Epitranscriptional modifications on ribosomal RNA (rRNA) are not static. Emerging evidence suggests these modifications are heterogeneous and can change, potentially regulating ribosome function.

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Ribosomal RNA (rRNA) contains numerous post-transcriptional modifications, known as epitranscriptional modifications.
  • These modifications expand the chemical and topological diversity of standard nucleosides within rRNA.

Purpose of the Study:

  • To review emerging evidence on the heterogeneity of rRNA modifications.
  • To explore the potential regulatory role of rRNA modifications in ribosome structure and function.
  • To discuss the implications of variable epitranscriptional landscapes.

Main Methods:

  • Literature review of recent studies on rRNA modifications.
  • Analysis of data on condition-specific variations in epitranscriptional landscapes.
  • Synthesis of current understanding and identification of open questions.

Main Results:

  • RRNA modifications are more diverse than previously assumed.
  • Epitranscriptional modification patterns can vary across different cellular conditions and developmental stages.
  • This heterogeneity suggests a dynamic role for rRNA modifications beyond constitutive structural elements.

Conclusions:

  • RRNA modifications are not merely inert components but can be dynamic and condition-dependent.
  • The functional implications of this heterogeneity in ribosome structure and function require further investigation.
  • Understanding epitranscriptional plasticity is crucial for a complete picture of ribosome biology.