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Updated: Oct 26, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Prostate Cancer Presenting with Pruritus and Cholestasis
Young Hee Kim1, Jin Myung Park1, Chang Don Kang1
1Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.
Jaundice, a rare paraneoplastic syndrome symptom, can occur with metastatic prostate cancer. This case highlights that jaundice improved with prostate cancer treatment, suggesting a paraneoplastic etiology.
Area of Science:
- Oncology
- Hepatology
- Endocrinology
Background:
- Prostate cancer is a leading cause of cancer in men.
- Paraneoplastic syndromes are rare complications of cancer.
- Jaundice is an uncommon manifestation of paraneoplastic syndromes.
Observation:
- A patient with metastatic prostate cancer presented with jaundice.
- No biliary obstruction or liver metastases were identified.
- Cholestasis was suspected to be caused by a paraneoplastic syndrome.
Findings:
- Jaundice resolved following treatment for prostate cancer.
- Interleukin-6 is implicated in paraneoplastic syndromes in existing literature.
- This case supports the link between prostate cancer and paraneoplastic cholestasis.
Implications:
- Highlights a rare presentation of prostate cancer.
- Suggests paraneoplastic syndrome as a differential diagnosis for unexplained cholestasis in prostate cancer patients.
- May prompt further research into the role of cytokines like IL-6 in cancer-related cholestasis.
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