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The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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Related Experiment Video

Updated: Oct 26, 2025

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Towards a synthetic cell cycle.

Lorenzo Olivi¹, Mareike Berger², Ramon N P Creyghton²

¹Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.

Nature Communications

|July 27, 2021

Summary

This summary is machine-generated.

Researchers are exploring synthetic biology to build artificial cells. This perspective discusses approaches to integrate essential cell cycle processes like DNA replication and division for a functional synthetic cell.

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Area of Science:

Synthetic biology
Cellular engineering
Biotechnology

Background:

Advancements in synthetic biology are enabling the bottom-up construction of artificial cells.
A functional cell cycle, involving DNA replication, segregation, growth, and division, is crucial for synthetic cell viability.
Current research focuses on recreating individual components of the cell cycle.

Purpose of the Study:

To review and discuss various approaches for recreating a functional cell cycle in synthetic cells.
To highlight the challenges and potential solutions for integrating cellular processes in an artificial cell.
To outline future directions for achieving an integrated synthetic cell cycle.

Main Methods:

Review of natural biological systems for cell cycle mechanisms.
Exploration of synthetic alternatives for cellular machinery.
Analysis of integration strategies for DNA replication, segregation, growth, and division.

Main Results:

Individual components of the synthetic cell cycle have been developed.
The integration and coordinated control of these components remain a significant challenge.
Multiple strategies exist for recreating essential cell cycle functions.

Conclusions:

Achieving a fully integrated synthetic cell cycle requires further research into control and coordination mechanisms.
The bottom-up assembly of synthetic cells with life-like properties is a key goal in synthetic biology.
Future work should focus on the holistic design of synthetic cell systems.