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SARS-CoV-2 Restructures the Host Chromatin Architecture
Ruoyu Wang1,2, Joo-Hyung Lee1, Feng Xiong1
1Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, 77030, TX, USA.
Biorxiv : the Preprint Server for Biology
|July 27, 2021
Summary
SARS-CoV-2 infection restructures host cell 3D genome architecture and epigenome. This viral impact weakens antiviral genes and alters inflammatory gene expression, impacting immune response.
Area of Science:
- Virology
- Epigenetics
- Genomics
Background:
- Over 190 million SARS-CoV-2 infections worldwide necessitate understanding viral impacts on host cells.
- Viruses are known to alter host chromatin, but SARS-CoV-2's role remains largely uncharacterized.
Conclusions:
- SARS-CoV-2 rewires host chromatin architecture and epigenome to deregulate immunological gene expression.
- The study provides insights into the molecular mechanisms underlying SARS-CoV-2-induced immune dysregulation.
- Findings lay the foundation for understanding the long-term epigenomic consequences of SARS-CoV-2 infection.
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