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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
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Brain structural differences in temporal lobe and frontal lobe epilepsy patients: A voxel-based morphometry and
Chun-Qiang Lu1,2, Grant P Gosden1, Lela Okromelidze1
1Department of Radiology, 6915Mayo Clinic, USA.
The Neuroradiology Journal
|July 27, 2021
Summary
Chronic recurrent seizures in temporal lobe epilepsy (TLE) cause lateralized hippocampal volume reduction. Frontal lobe epilepsy (FLE) did not show focal atrophy, highlighting epilepsy-onset zone variations in brain structure changes.
Area of Science:
- Neuroimaging
- Epilepsy Research
- Brain Morphology
Background:
- Conflicting reports exist on brain volume changes in focal epilepsy.
- Understanding structural differences is crucial for epilepsy management.
Purpose of the Study:
- To investigate brain structure differences in temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE).
- To analyze brain volumes in patients with seizure-onset zones confirmed by intracranial monitoring.
Main Methods:
- Retrospective analysis of 120 TLE patients, 86 FLE patients, and 54 controls.
- Voxel-based morphometry (VBM) and vertex-based surface analysis were employed.
- Hippocampal and thalamic volumes were specifically analyzed.
Main Results:
- Significant, side-specific hippocampal gray matter volume reduction in left TLE (LTLE) and right TLE (RTLE) groups compared to controls.
- LTLE patients showed bilateral medial and inferior thalamus volume differences versus controls.
- No focal gray matter atrophy was observed in FLE patients.
Conclusions:
- Morphometric brain changes vary based on epilepsy onset zone.
- Findings offer insights into the natural history of drug-resistant focal epilepsies.
