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Neutrophil-to-lymphocyte Ratio Predicts the Outcome of Cerebral Venous Thrombosis

Jiawei Zhao1, Kai Liu1, Shen Li1

  • 1Department of Neurology, Zhengzhou University First Affiliated Hospital, Zhengzhou, Henan, China.

Current Neurovascular Research
|July 27, 2021
PubMed

Insights

Elevated Neutrophil-to-Lymphocyte Ratio (NLR) indicates a higher risk of poor outcomes in Cerebral Venous Thrombosis (CVT) patients. This finding highlights NLR as a significant predictor for mortality and adverse events in CVT.

Area of Science:

  • Neuroscience
  • Hematology
  • Cardiovascular Research

Background:

  • The Neutrophil-to-Lymphocyte Ratio (NLR) is recognized as a predictor of poor prognosis in cardiovascular diseases.
  • The prognostic value of NLR in Cerebral Venous Thrombosis (CVT) patients remains understudied.

Purpose of the Study:

  • To investigate the association between NLR and clinical outcomes, including mortality, in patients diagnosed with CVT.
  • To evaluate NLR's predictive ability for mortality in CVT patients compared to other leukocyte counts.

Main Methods:

  • Retrospective analysis of 360 consecutive CVT patients (November 2011-April 2019).
  • Poor outcome defined as modified Rankin Scale (mRS) 3-6.
  • Multivariate logistic and Cox regression analyses were used to assess the relationship between NLR and outcomes. Receiver Operating Characteristic (ROC) analysis evaluated predictive performance.

Main Results:

  • NLR was significantly associated with a higher risk of poor outcome (aOR=1.06) and mortality (aOR=1.08) in CVT patients.
  • NLR demonstrated superior predictive ability for mortality (AUC=0.81) compared to total and differential leukocyte counts.
  • An NLR cutoff of 5.6 predicted mortality with 84.2% sensitivity and 69.9% specificity. High NLR (>5.6) was linked to significantly higher mortality rates (aHR=5.65).

Conclusions:

  • Elevated NLR is a significant independent predictor of poor outcomes and mortality in patients with Cerebral Venous Thrombosis.
  • NLR serves as a valuable prognostic biomarker for risk stratification in CVT management.
Abstract

Keywords:
Cerebral Venous Thrombosis (CVT).Neutrophil-to-lymphocyte ratiocerebral venous thrombosismortalitypredictorsprognosis

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