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Diabefit as a Modifier of Fructose-induced Impairment of Cardio-vascular System

Ashot Avagimyan1, Lilit Sukiasyan2, Lev Kakturskiy3

  • 1Yerevan State Medical University after M. Heratsi, Yerevan, Republic of Armenia.

Current Problems in Cardiology
|July 27, 2021
PubMed

Insights

Fructose overload in diabetic rats induced cardiovascular damage by increasing oxidative stress. The herbal collection "Diabefit" mitigated these harmful effects, restoring antioxidant balance and protecting cardiovascular homeostasis.

Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Diabetology

Background:

  • Cardiovascular diseases are a major global health concern, particularly in diabetic patients.
  • Fructose, often used by diabetics, poses a risk of cardiotoxicity and cardiovascular homeostasis destabilization.
  • Understanding fructose's impact on cardiovascular health in diabetes is clinically urgent.

Purpose of the Study:

  • To investigate the cardiotoxic effects of fructose in a diabetic rat model.
  • To evaluate the potential protective role of the herbal collection "Diabefit" against fructose-induced cardiovascular damage.

Main Methods:

  • Sixty rats were used to model fructose overload.
  • Fructose-induced overload was induced using a diabetic fructose supplement.
  • The herbal collection "Diabefit" was administered as an infusion alongside a high-fructose diet.
  • Cardiovascular markers including MDA, SOD, NO, and ET-1 were analyzed.

Main Results:

  • Fructose overload significantly increased MDA, ET-1, and NO concentrations.
  • Fructose overload significantly decreased SOD levels, indicating reduced antioxidant reserve.
  • "Diabefit" administration reversed these changes, increasing SOD and decreasing MDA, ET-1, and NO.
  • Detected changes were linked to fructose-induced inhibition and "Diabefit"-mediated restoration of SOD activity.

Conclusions:

  • Fructose consumption induces cardiotoxicity and oxidative stress in diabetic rats.
  • "Diabefit" demonstrates protective effects against fructose-induced cardiovascular damage.
  • The herbal collection may restore antioxidant balance and improve cardiovascular homeostasis in this context.

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