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Updated: Oct 26, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

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Effect of different bile acids on the intestine through enterohepatic circulation based on FXR

Junwei Xiang1,2, Zhengyan Zhang1,2, Hongyi Xie1,2

  • 1Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou, China.

Gut Microbes
|July 27, 2021
PubMed

Insights

Farnesoid X receptor (FXR), activated by bile acids (BAs), influences gut health and metabolism. This review explores how different BAs impact the intestine via FXR, paving the way for novel therapeutic strategies.

Area of Science:

  • Metabolic regulation
  • Hepatology
  • Gastroenterology

Background:

  • Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs).
  • FXR plays a crucial role in regulating glucose, lipid, and sterol metabolism.
  • FXR activation is linked to improvements in obesity, liver damage, cholestasis, and inflammatory diseases.

Purpose of the Study:

  • To review the effects of diverse bile acids on the intestinal tract.
  • To examine these effects through the lens of the enterohepatic circulation and FXR signaling.
  • To provide a foundation for developing new therapeutic approaches targeting intestinal BA metabolism.

Main Methods:

  • Literature review focusing on bile acids and FXR.
  • Analysis of the enterohepatic circulation's role in BA-gut interactions.
  • Synthesis of current understanding of FXR's intestinal functions.

Main Results:

  • Bile acids exert significant regulatory effects on the intestinal tract.
  • FXR is a key mediator of these BA-induced intestinal effects.
  • Diverse BA profiles influence distinct metabolic and inflammatory pathways within the intestine.

Conclusions:

  • Bile acids and FXR signaling are critical regulators of intestinal homeostasis.
  • Understanding BA-FXR interactions in the intestine opens avenues for treating metabolic and inflammatory conditions.
  • Targeting intestinal FXR offers potential for novel therapeutic interventions.
Keywords:
Bile acidsFXRenterohepatic circulationintestine

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