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Physical activity volume in patients with arrhythmogenic cardiomyopathy is associated with recurrence after

Pasquale Vergara1, Luigi Pannone2, Francesco Calvo2

  • 1Arrhythmology Unit and Clinical Electrophysiology Laboratories, Ospedale San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy. pasqualevergara@hotmail.com.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|July 27, 2021
PubMed

Insights

Intense physical activity (PA) exceeding 584 METs/week is linked to higher ventricular tachycardia (VT) recurrence after ablation in arrhythmogenic cardiomyopathy (ACM) patients. Late potential abolition independently predicts lower VT recurrence.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Genetics

Background:

  • Arrhythmogenic cardiomyopathy (ACM) is a genetic heart disease characterized by ventricular arrhythmias.
  • Catheter ablation (CA) is a treatment option for ventricular tachycardia (VT) in ACM patients.
  • The impact of physical activity (PA) levels on VT recurrence post-ablation in ACM is not fully understood.

Purpose of the Study:

  • To investigate the association between intense physical activity (PA) and the recurrence of ventricular tachycardia (VT) after catheter ablation (CA) in patients diagnosed with arrhythmogenic cardiomyopathy (ACM).

Main Methods:

  • Retrospective analysis of 63 ACM patients who underwent VT ablation.
  • Quantification of weekly PA using the International Physical Activity Questionnaire (IPAQ) in 51 patients.
  • Kaplan-Meier analysis and Cox multivariate analysis to assess VT-free survival and predictors of recurrence.

Main Results:

  • Patients with VT recurrence exhibited significantly higher weekly PA levels (2303.1 METs) compared to those without recurrence (1043.5 METs).
  • A PA threshold of 584 METs/week identified high-PA individuals (n=34) at greater risk for VT recurrence (50.0% recurrence) versus low-PA individuals (n=17, 82.4% VT-free survival).
  • High PA (≥584 METs/week) and absence of late potential abolition were independent predictors of VT recurrence (HR=2.61 and HR=0.38, respectively).

Conclusions:

  • Physical activity levels ≥584 METs/week are associated with an increased risk of VT recurrence post-ablation in ACM patients.
  • Late potential abolition during ablation is a significant independent predictor of reduced VT recurrence.
  • Risk stratification considering PA levels and electrophysiological findings may optimize post-ablation management in ACM.
Abstract

Keywords:
Arrhythmogenic cardiomyopathyCatheter ablationPhysical activityRight ventricular dysplasiaVentricular tachycardia

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