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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Lymphatic Vessels and Lymph Transport01:16

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Related Experiment Video

Updated: Oct 26, 2025

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

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Weight loss does not decrease risk of breast cancer-related arm lymphedema.

Sacha A Roberts1, Tessa C Gillespie1, Amy M Shui2

  • 1Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Cancer
|July 27, 2021
PubMed
Summary
This summary is machine-generated.

Weight loss alone may not prevent breast cancer-related lymphedema (BCRL). This study found no significant protective effect of weight change on BCRL development in breast cancer patients.

Keywords:
breast cancerbreast cancer-related lymphedemalymphedemaweight change

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Lymphedema Research

Background:

  • Breast cancer surgery can lead to long-term complications such as breast cancer-related lymphedema (BCRL).
  • Understanding risk factors for BCRL is crucial for patient management and quality of life.

Purpose of the Study:

  • To investigate the association between postoperative weight changes and the incidence of BCRL.
  • To determine if weight loss or gain influences BCRL development after breast cancer surgery.

Main Methods:

  • A prospective cohort study of 1161 women undergoing unilateral breast surgery for breast cancer (2005-2020).
  • Arm volume was measured preoperatively, postoperatively, and every 6-12 months for a mean follow-up of 49.1 months.
  • BCRL was defined as a ≥10% relative increase in ipsilateral arm volume at least 3 months post-surgery.

Main Results:

  • 92 patients (7.9%) developed BCRL.
  • Net weight loss or gain from baseline to final follow-up did not significantly reduce the risk of developing BCRL (HR, 1.38; 95% CI, 0.89-2.13; P = .152).

Conclusions:

  • Weight loss, while beneficial for general health, may not be sufficient to decrease the risk of BCRL.
  • Further research into comprehensive lifestyle management strategies is warranted for BCRL prevention.