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Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells

Brady G Strittmatter1, Travis J Jerde2, Peter C Hollenhorst3

  • 1Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, United States of America.

Plos Genetics
|July 27, 2021
PubMed
Summary

The TMPRSS2/ERG gene rearrangement drives prostate cancer by activating the ERG transcription factor. ERG promotes tumor formation and cell migration, with phosphorylation at serine 96 being crucial for its oncogenic function.

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