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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Managing Complex Perianal Fistulizing Disease.

Karina E Pedersen1, Amy L Lightner2

  • 1College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA.

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
|July 27, 2021
PubMed
Summary
This summary is machine-generated.

Perianal Crohn's disease significantly impacts quality of life, with limited success from current treatments. Emerging therapies like stem cells offer improved efficacy and reduced incontinence risk for this challenging condition.

Keywords:
Crohn's diseasecell therapyileostomyperianal fistulaproctectomy

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Area of Science:

  • Gastroenterology and immunology
  • Regenerative medicine

Background:

  • Perianal Crohn's disease affects up to 33% of patients, causing significant morbidity and reduced quality of life.
  • Conventional medical and surgical treatments for perianal fistulizing Crohn's disease have limited long-term efficacy, often resulting in chronic setons or incontinence.
  • Up to 40% of patients with perianal fistulizing disease ultimately require a stoma.

Purpose of the Study:

  • To review the efficacy of emerging therapies for perianal Crohn's disease.
  • To compare mesenchymal stem cell therapy and laser therapy with conventional treatments.
  • To highlight the potential of novel interventions to improve outcomes and reduce the need for stomas.

Main Methods:

  • Review of current literature on perianal Crohn's disease management.
  • Analysis of outcomes for conventional therapies (medical and surgical).
  • Evaluation of emerging treatments including mesenchymal stem cells and laser therapy.

Main Results:

  • Conventional therapies achieve durable remission in only about 33% of patients.
  • Mesenchymal stem cell therapy shows promise with improved efficacy and no risk of incontinence.
  • Laser therapy is an emerging option, but outcomes data are still developing.

Conclusions:

  • Perianal Crohn's disease remains a challenging condition with significant unmet needs.
  • Mesenchymal stem cell therapy represents a promising advancement for managing perianal fistulizing Crohn's disease.
  • Further research into novel therapies is crucial to improve patient outcomes and minimize the need for stomas.