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Andrographolide and its derivatives: Current achievements and future perspectives
Hang Zhang1, Shufeng Li1, Yongsheng Si1
1Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.
European Journal of Medicinal Chemistry
|July 27, 2021
Summary
Andrographolide, a natural compound, and its modified derivatives show broad therapeutic potential for various diseases, including cancer. Research over the past decade has focused on optimizing their drug design and understanding their mechanisms for enhanced efficacy.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Andrographolide, derived from *Andrographis paniculata*, exhibits diverse biological activities.
- Previous research has identified anti-tumor, anti-bacterial, anti-inflammatory, and anti-viral properties.
- Significant efforts have been made to develop andrographolide derivatives with improved pharmacokinetic profiles.
Purpose of the Study:
- To review the therapeutic potential of andrographolide and its derivatives.
- To highlight advancements in drug design, pharmacokinetics, and mechanistic studies over the last decade.
- To provide insights into future perspectives, challenges, and limitations in the field.
Main Methods:
- Literature review focusing on studies from the past ten years.
- Analysis of chemical structural modifications and their impact on biological activity.
- Investigation of molecular and cellular mechanisms of action.
Main Results:
- Development of andrographolide derivatives with enhanced bioavailability and druggability.
- Detailed understanding of the mechanisms underlying their pharmacological effects.
- Demonstration of therapeutic potential across a range of diseases, including various cancers.
Conclusions:
- Andrographolide and its derivatives represent promising candidates for drug discovery and development.
- Further research into drug targets and therapeutic applications is warranted.
- This review provides a critical overview to guide future research and therapeutic strategies.
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