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Related Experiment Video

Updated: Oct 26, 2025

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

High-throughput hit-squad tackles trypanosomes.

Alexander D Cook¹, Matthew K Higgins¹

¹Department of Biochemistry, University of Oxford, Oxford, UK.

Trends in Parasitology

|July 28, 2021

Summary

This summary is machine-generated.

Developing a vaccine against African trypanosomes, which cause disease in humans and livestock, is challenging due to parasite immune evasion. A new high-throughput screen offers hope for future vaccine development against these parasites.

Keywords:

invariant surface proteins trypanosomes vaccines

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Published on: December 30, 2012

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Last Updated: Oct 26, 2025

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

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Published on: November 5, 2021

High-throughput Gene Tagging in Trypanosoma brucei

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Published on: August 12, 2016

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

Area of Science:

Parasitology
Immunology
Vaccine Development

Background:

African trypanosomes are protozoan parasites responsible for significant human and livestock diseases.
Current control strategies are limited, and a vaccine remains elusive due to the parasites' sophisticated immune evasion tactics.

Purpose of the Study:

To identify novel targets for therapeutic intervention and vaccine development against African trypanosomes.
To overcome the challenge of immune evasion posed by these parasites.

Main Methods:

A bold, high-throughput screening approach was employed.
The screen aimed to identify vulnerabilities in the parasite's biology or immune evasion mechanisms.

Main Results:

The study successfully utilized a high-throughput screen to analyze potential vaccine targets.
This approach provides a promising foundation for developing effective vaccines against African trypanosomes.

Conclusions:

The high-throughput screen represents a significant advancement in the search for a vaccine against African trypanosomes.
This research offers renewed hope for controlling devastating diseases caused by these parasites.