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Fractures and Osteoporosis in Patients With Diabetes With Charcot Foot

Oliver Christian Rabe1,2, Matilde Winther-Jensen2,3, Kristine Højgaard Allin2,3,4

  • 1Department of Endocrinology, Copenhagen Diabetes Foot Center (CODIF), Copenhagen, Denmark.

Diabetes Care
|July 28, 2021
PubMed

Insights

Patients with diabetes and Charcot foot face a higher risk of fractures and osteoporosis. This study confirms an increased risk of bone complications in diabetic individuals with Charcot foot.

Area of Science:

  • Endocrinology
  • Orthopedics
  • Epidemiology

Background:

  • Charcot foot is a severe diabetic complication affecting foot and ankle bones and joints.
  • The association between Charcot foot and increased risk of osteoporosis and fractures in diabetic patients remains unclear.

Purpose of the Study:

  • To investigate if diabetic patients with Charcot foot have a higher risk of fractures and/or osteoporosis compared to diabetic patients without Charcot foot.

Main Methods:

  • A nationwide, population-based, matched cohort study in Denmark (1995-2018).
  • 1,602 patients with diabetes and Charcot foot were matched with 16,296 controls.
  • Logistic regression analyzed odds ratios (ORs) for fracture and osteoporosis using Danish National Patient Register data.

Main Results:

  • Diabetic patients with Charcot foot showed increased risk for any fracture (OR 1.8), lower-leg fracture (OR 2.4), foot fracture (OR 2.9), and osteoporotic fracture (OR 1.3).
  • A higher risk of osteoporosis was observed in patients with Charcot foot (OR 1.3).

Conclusions:

  • Diabetic patients diagnosed with Charcot foot exhibit an elevated risk for fractures.
  • Individuals with diabetes and Charcot foot also face an increased likelihood of developing osteoporosis.
Abstract

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