Related Experiment Video
Updated: Oct 26, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides
Zunera Khalid1, Sana Aslam1,2, Matloob Ahmad3
1Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Abstract:
A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]-N'-arylmethyleneacetohydrazides (5a-o) were synthesized and screened for their anti-HIV-1 and cytotoxicity activity. Out of fifteen pyrazolobenzothiazine-based hydrazones, thirteen were found to be active inhibitors of HIV with EC50 values <20 μM. Moreover, the cytotoxicity results showed that most of the compounds were toxic to PBM, CEM and Vero cell lines. This information could be used for structural modifications to acquire good candidates of HIV drugs.
Related Concept Videos
Diazonium Group Substitution: –OH and –H
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Retrovirus Life Cycles
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

