Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Second generation questions about senescent neuron loss.

¹Department of Biological Sciences, Stanford University, CA 94305.

Neurobiology of Aging

|November 1, 1987

Summary

This review highlights growing agreement on senescent neuron loss, focusing on the mechanisms, consequences, and variability of this neuronal change.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons.

Molecular psychiatry·2011

Same author

SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization.

Molecular psychiatry·2009

Same author

Viral caspase inhibitor p35, but not crmA, is neuroprotective in the ischemic penumbra following experimental stroke.

Neuroscience·2007

Same author

The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus.

Neuroscience·2007

Same author

Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation.

The European journal of neuroscience·2004

Same author

Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memory.

Hippocampus·2004

Area of Science:

Neuroscience
Aging Research
Cellular Biology

Background:

Emerging consensus on senescent neuron loss.
Understanding the scale and location of neuronal changes in aging.

Purpose of the Study:

Identify key unanswered questions regarding senescent neuron loss.
Explore mechanisms, compensatory processes, and functional impacts.
Investigate sources of individual variability in neuronal aging.

Main Methods:

Review of existing literature on neuronal senescence.
Synthesis of findings on neuron loss and density.
Identification of critical research gaps.

Main Results:

Consensus on the magnitude and location of senescent neuron loss.
Identification of selective neuron death as a key area.
Recognition of compensatory mechanisms and their importance.

Conclusions:

Urgent need to investigate mechanisms of selective neuron death.
Further research required on functional consequences of neuronal shrinkage and density loss.
Understanding individual variability in these aging processes is crucial.

Related Experiment Videos