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Published on: July 5, 2021
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Pediatric Skull Base Tumors: A Management Challenge.
Matheus F M Ballestero1,2, Stephanie N F de Souza2, Romilto C Pacheco Neto2
1Department of Medicine, Federal University of São Carlos, São Carlos, Brazil.
Journal of Pediatric Neurosciences
|July 28, 2021
Summary
Pediatric skull base tumor surgery presents challenges, with significant rates of neurological deficits and tumor recurrence. Outcomes highlight the need for specialized care in managing these complex pediatric cranial base lesions.
Area of Science:
- Pediatric neurosurgery
- Pediatric oncology
- Cranial base surgery
Background:
- Skull base tumors in children are diverse and pose significant challenges for pediatric neurosurgeons.
- Limited literature exists on the long-term evolution, complications, and outcomes of pediatric skull base tumor surgery.
Purpose of the Study:
- To analyze surgical outcomes, complications, and long-term results in pediatric patients undergoing skull base tumor surgery.
- To compare findings with existing literature on pediatric skull base tumors.
Main Methods:
- Retrospective analysis of 17 children who underwent surgery for cranial base lesions between 2000 and 2018.
- Comprehensive literature review of 115 children operated on for skull base tumors.
- Statistical analysis included Chi-squared, Fisher's exact, and Mann-Whitney U tests.
Main Results:
- Seventeen pediatric patients underwent skull base surgery for various tumor types.
- Gross total resection was achieved in 35.3% of cases; 70.6% had benign histology.
- Significant morbidity was observed, with 76.4% experiencing residual neurological deficits and a 17.6% recurrence rate.
Conclusions:
- Pediatric skull base tumors are challenging due to their varied pathology.
- These tumors can lead to substantial morbidity and mortality in children.
- Effective management strategies are crucial for improving outcomes in pediatric skull base tumor patients.
