Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.2K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.2K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

1.2K
The pathophysiology of pneumonia involves the following steps:
1.2K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

209
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
209
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

84
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
84
Infection01:20

Infection

9.4K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
9.4K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

341
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
341

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ulcerative colitis: Timeline to a cure.

World journal of gastroenterology·2025
Same author

Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide.

World journal of gastroenterology·2022
Same author

Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury.

Biomedicines·2022
Same author

Hydrogen peroxide and disease: towards a unified system of pathogenesis and therapeutics.

Molecular medicine (Cambridge, Mass.)·2020
Same author

Systemic Lupus Erythematosus: Pathogenesis at the Functional Limit of Redox Homeostasis.

Oxidative medicine and cellular longevity·2019
Same author

Can ulcerative colitis be cured?

Discovery medicine·2019

Related Experiment Video

Updated: Oct 26, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.2K

Sepsis: Evidence-based pathogenesis and treatment.

Jay Pravda1

  • 1Inflammatory Disease Research Centre, Therashock LLC, Palm Beach Gardens, FL 33410, United States. jaypravda1@gmail.com.

World Journal of Critical Care Medicine
|July 28, 2021
PubMed
Summary

Sepsis involves a hypermetabolic state producing toxic hydrogen peroxide (H2O2). Reducing H2O2 levels may offer a novel therapy for sepsis, restoring normal organ function and vascular responsiveness.

Keywords:
Hydrogen peroxideRedox homeostasisSepsisSeptic shockThiosulfate

More Related Videos

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

354
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.3K

Related Experiment Videos

Last Updated: Oct 26, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.2K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

354
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.3K

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Critical Care Medicine

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • A hallmark of sepsis is a hypermetabolic state, increasing cellular energy demands.
  • This metabolic state elevates the production of hydrogen peroxide (H2O2), a reactive oxygen species.

Purpose of the Study:

  • To explore the causal role of hydrogen peroxide (H2O2) in sepsis pathogenesis.
  • To review evidence supporting H2O2 as a key mediator of sepsis-induced organ dysfunction.
  • To discuss therapeutic strategies targeting H2O2 reduction for sepsis treatment.

Main Methods:

  • Review of existing literature on sepsis pathophysiology and oxidative stress.
  • Analysis of the biochemical mechanisms linking hypermetabolism to H2O2 production.
  • Correlation of H2O2 levels with clinical manifestations and laboratory findings in sepsis.

Main Results:

  • Increased oxidative phosphorylation during sepsis generates excessive mitochondrial hydrogen peroxide (H2O2).
  • Elevated H2O2 overwhelms cellular antioxidant capacity, leading to cellular damage and organ dysfunction.
  • Toxic H2O2 levels in the blood correlate with septic shock and its associated abnormalities.

Conclusions:

  • Hydrogen peroxide (H2O2) plays a critical role in the pathogenesis of sepsis.
  • Therapeutic interventions aimed at reducing H2O2 levels show promise for sepsis treatment.
  • Restoring redox homeostasis by managing H2O2 is essential for improving organ function and vascular responsiveness in sepsis.